Question 1
A patient with hypertension is prescribed hydrochlorothiazide. The mechanism of action of hydrochlorothiazide involves:
- A. Inhibiting sodium reabsorption in the kidneys
- B. Blocking calcium channels in the blood vessels
- C. Increasing the excretion of potassium
- D. Relaxing vascular smooth muscle
Show answer and rationale
Correct answer: A — Inhibiting sodium reabsorption in the kidneys
Step 1: Hydrochlorothiazide is a thiazide diuretic. Step 2: Thiazide diuretics work by inhibiting sodium reabsorption in the kidneys. Step 3: By blocking sodium reabsorption, hydrochlorothiazide increases water excretion, reducing blood volume and lowering blood pressure. Step 4: Therefore, the correct answer is A: Inhibiting sodium reabsorption in the kidneys. Summary: - Option B (Blocking calcium channels) is incorrect because hydrochlorothiazide does not affect calcium channels. - Option C (Increasing the excretion of potassium) is incorrect as thiazide diuretics can cause hypokalemia by increasing potassium excretion. - Option D (Relaxing vascular smooth muscle) is incorrect as this is not the primary mechanism of action of hydrochlorothiazide.