Question 1
A 12 years-old boy has a severe asthmatic attack with wheezing. His arterial pO2 is 60 mmHg and pCO2 is 30 mmHg. His:
- A. FEV1/FVC % is increased
- B. V/Q ratio is increased in the affected areas of his lung
- C. Arterial pCO2 is higher than normal because of inadequate gas exchange
- D. Arterial pCO2 is lower than normal because hypoxemia is causing him to hyperventilate
Show answer and rationale
Correct answer: D — Arterial pCO2 is lower than normal because hypoxemia is causing him to hyperventilate
In a severe asthma attack, bronchoconstriction obstructs airways, reducing airflow, especially on expiration, causing wheezing. FEV1/FVC decreases (<80%) as FEV1 drops more than FVC due to obstruction, not increases. The ventilation/perfusion (V/Q) ratio in affected areas falls, as ventilation is blocked while perfusion persists, causing hypoxemia (PaO2 60 mmHg vs. 75-100 mmHg normal). Arterial PCO2 (30 mmHg vs. 35-45 mmHg) is lower, not higher, because hypoxemia stimulates hyperventilation via peripheral chemoreceptors, expelling CO2 faster than it builds up, a compensatory response in acute asthma. Inadequate gas exchange lowers PaO2, not PCO2, here. Option D correctly ties low PCO2 to hyperventilation driven by hypoxia, aligning with asthma's physiology where obstruction impairs oxygen uptake but CO2 clearance accelerates with increased respiratory effort.