Question 1
The nurse in charge must monitor a patient receiving chloramphenicol for adverse drug reaction. What is the most toxic reaction to chloramphenicol?
- A. Lethal arrhythmias
- B. Malignant hypertension
- C. Status epilepticus
- D. Bone marrow suppression
Show answer and rationale
Correct answer: D — Bone marrow suppression
Chloramphenicol is an antibiotic reserved for serious infections due to its potential for severe toxicity, with bone marrow suppression (Choice D) being the most dangerous adverse reaction. This condition can manifest as aplastic anemia, a potentially fatal reduction in blood cell production, affecting red cells, white cells, and platelets. The risk arises because chloramphenicol inhibits protein synthesis in bone marrow mitochondria, leading to suppressed hematopoiesis. Lethal arrhythmias (Choice A) are not a primary concern with this drug, as it doesn't directly affect cardiac ion channels. Malignant hypertension (Choice B) is unrelated, as chloramphenicol doesn't influence vascular tone or blood pressure significantly. Status epilepticus (Choice C), a prolonged seizure state, is also not associated, as the drug's neurotoxicity is more likely to cause peripheral neuropathy than seizures. Bone marrow suppression can lead to life-threatening infections, bleeding, or anemia, requiring close monitoring (e.g., regular complete blood counts). Its severity and irreversibility in some cases make it the most toxic reaction, confirming Choice D as the correct answer.