Question 1
On which biological theory of aging is the prevention of telomere shortening based?
- A. Genetic research
- B. Caloric restriction
- C. Oxidative stress
- D. Cross-link
Show answer and rationale
Correct answer: A — Genetic research
The correct answer is A: Genetic research. Telomere shortening is primarily based on the theory of cellular senescence, which is related to genetic research. Telomeres are protective caps at the end of chromosomes that shorten with each cell division. Genetic research has shown that telomere shortening is associated with aging and age-related diseases. Caloric restriction, oxidative stress, and cross-link theories of aging are not directly linked to telomere shortening. Caloric restriction focuses on extending lifespan by reducing calorie intake, oxidative stress theory suggests that aging is caused by cumulative damage from reactive oxygen species, and cross-link theory emphasizes the accumulation of non-reversible bonds between molecules as a cause of aging.