Five gastrointestinal questions with answers
Cover the key. Write the first action. Then open the rationale and name why the other choices fail.
Question 1
A 55-year-old man presents complaining of frequent foul-smelling stools, excess gas, 10-pound weight loss, and unsteadiness of gait. His past history includes multiple prior episodes of small intestinal obstruction arising from adhesions from abdominal surgery for trauma. He still complains of occasional periumbilical pain after eating, and has generalized aches and pains and chronic soreness around his mouth. He takes a proton pump inhibitor for gastroesophageal reflux. Apart from his previous scars, his abdominal exam is normal. He has absent ankle jerks and he is unable to maintain an upright posture gait with his feet together once he closes his eyes. His investigations reveal stool fat levels of $15 \mathrm{~g} / 24$ hours. His labs are notable for macrocytic anemia, an elevated alkaline phosphatase, and a low serum albumin. CT of his abdomen reveals some mildly dilated small bowel loops. Which of the following statements are incorrect?
- A. A hydrogen breath test is likely to show bacterial overgrowth
- B. His serum folic acid levels may be elevated and his vitamin B12 is likely to be low
- C. His proton pump inhibitor is probably contributing to his symptoms
- D. The finding of partial villous atrophy suggests that his primary problem is the result of mucosal enteropathy
Show answer and rationale
Correct answer: D — The finding of partial villous atrophy suggests that his primary problem is the result of mucosal enteropathy
He has fat malabsorption and steatorrhea secondary to bacterial overgrowth from intestinal stasis arising from his adhesions. Bacterial overgrowth leads to vitamin B12 deficiency from bacterial consumption of B12. His B12 deficiency has caused him to develop subacute combined degeneration of the cord with a positive Romberg's sign, stomatitis, and evidence of a peripheral neuropathy. Folic acid levels may increase as folate is produced by luminal bacteria. The reduction in gastric acid by proton pump inhibitors increases intestinal bacteria and is probably exacerbating bacterial overgrowth in this setting. Acid is also needed to release protein-bound vitamin B12 from food, and individuals who take PPIs absorb less vitamin B12 from food but rarely to such an extent that it leads to vitamin B12 deficiency. Many patients with small bowel bacterial overgrowth have mildly abnormal intestinal villi, which occur secondary to the effect of excess bacteria. Since his bacterial overgrowth is related to his anatomy, he will require regular cycles of antibiotics.
Question 2
A 55-year-old man presents complaining of frequent foul-smelling stools, excess gas, 10-pound weight loss, and unsteadiness of gait. His past history includes multiple prior episodes of small intestinal obstruction arising from adhesions from abdominal surgery for trauma. He still complains of occasional periumbilical pain after eating, and has generalized aches and pains and chronic soreness around his mouth. He takes a proton pump inhibitor for gastroesophageal reflux. Apart from his previous scars, his abdominal exam is normal. He has absent ankle jerks and he is unable to maintain an upright posture gait with his feet together once he closes his eyes. His investigations reveal stool fat levels of $15 \mathrm{~g} / 24$ hours. His labs are notable for macrocytic anemia, an elevated alkaline phosphatase, and a low serum albumin. CT of his abdomen reveals some mildly dilated small bowel loops. Which of the following statements are incorrect?
- A. A hydrogen breath test is likely to show bacterial overgrowth
- B. His serum folic acid levels may be elevated and his vitamin B12 is likely to be low
- C. His proton pump inhibitor is probably contributing to his symptoms
- D. The finding of partial villous atrophy suggests that his primary problem is the result of mucosal enteropathy
Show answer and rationale
Correct answer: D — The finding of partial villous atrophy suggests that his primary problem is the result of mucosal enteropathy
He has fat malabsorption and steatorrhea secondary to bacterial overgrowth from intestinal stasis arising from his adhesions. Bacterial overgrowth leads to vitamin B12 deficiency from bacterial consumption of B12. His B12 deficiency has caused him to develop subacute combined degeneration of the cord with a positive Romberg's sign, stomatitis, and evidence of a peripheral neuropathy. Folic acid levels may increase as folate is produced by luminal bacteria. The reduction in gastric acid by proton pump inhibitors increases intestinal bacteria and is probably exacerbating bacterial overgrowth in this setting. Acid is also needed to release protein-bound vitamin B12 from food, and individuals who take PPIs absorb less vitamin B12 from food but rarely to such an extent that it leads to vitamin B12 deficiency. Many patients with small bowel bacterial overgrowth have mildly abnormal intestinal villi, which occur secondary to the effect of excess bacteria. Since his bacterial overgrowth is related to his anatomy, he will require regular cycles of antibiotics.
Question 3
A 25-year-old dental technician has noticed a 10-pound weight loss despite increased appetite, generalized weakness, and constipation with infrequent but unusually voluminous and malodorous stools. On physical examination, he is thin, pale, and appears tired. His abdomen is protuberant but soft. Labs reveal a microcytic anemia. Which of the following is least likely to be helpful?
- A. Upper endoscopy
- B. 72-hour stool collection for fecal fat
- C. CT scan of the abdomen
- D. Colonoscopy
Show answer and rationale
Correct answer: D — Colonoscopy
This young man with weight loss, malodorous, bulky stools, increased appetite, and iron deficiency anemia has celiac disease as the most likely diagnosis. Patients occasionally may feel constipated; however, the stools are unusually bulky and consistently malodorous. The disease is diagnosed by biopsy of the small bowel by upper endoscopy (Answer A). Elevated anti-endomysial antibodies are highly suggestive. Fat malabsorption can be rigorously established by fecal fat collection. The differential diagnosis includes chronic pancreatitis, which is best evaluated by CT scan. A colonoscopy is helpful to evaluate iron deficiency anemia to rule out colonic tumors or other causes of occult blood loss or to assess for inflammatory bowel disease. However, in this patient with malabsorption, increased appetite, and young age, sprue is more likely to explain the constipation and iron deficiency anemia. He does not have abdominal pain, blood in the stools, or diarrhea, the most common symptoms of inflammatory bowel disease. Colonoscopy will be less useful.
Question 4
A 25-year-old dental technician has noticed a 10-pound weight loss despite increased appetite, generalized weakness, and constipation with infrequent but unusually voluminous and malodorous stools. On physical examination, he is thin, pale, and appears tired. His abdomen is protuberant but soft. Labs reveal a microcytic anemia. Which of the following is least likely to be helpful?
- A. Upper endoscopy
- B. 72-hour stool collection for fecal fat
- C. CT scan of the abdomen
- D. Colonoscopy
Show answer and rationale
Correct answer: D — Colonoscopy
This young man with weight loss, malodorous, bulky stools, increased appetite, and iron deficiency anemia has celiac disease as the most likely diagnosis. Patients occasionally may feel constipated; however, the stools are unusually bulky and consistently malodorous. The disease is diagnosed by biopsy of the small bowel by upper endoscopy (Answer A). Elevated anti-endomysial antibodies are highly suggestive. Fat malabsorption can be rigorously established by fecal fat collection. The differential diagnosis includes chronic pancreatitis, which is best evaluated by CT scan. A colonoscopy is helpful to evaluate iron deficiency anemia to rule out colonic tumors or other causes of occult blood loss or to assess for inflammatory bowel disease. However, in this patient with malabsorption, increased appetite, and young age, sprue is more likely to explain the constipation and iron deficiency anemia. He does not have abdominal pain, blood in the stools, or diarrhea, the most common symptoms of inflammatory bowel disease. Colonoscopy will be less useful.
Question 5
A 66-year-old woman, a recently retired social worker who cares for her disabled husband, has been experiencing left lower quadrant discomfort. For the past few months, she has been having bowel movements every other day, which is a change from her usual once or twice per day. She has a long history of noninsulin-dependent diabetes mellitus, arthritis, hypothyroidism, and hypertension. Medications are glyburide $5 \mathrm{mg}$, levothyroxine $0.1 \mathrm{mg}$, and diltiazem (extended release) $240 \mathrm{mg}$ four times a day (previously managed on propranolol but changed on her last visit to diltiazem because of depressed mood), and ibuprofen as needed. She is very worried about colon cancer although she had a normal colonoscopy last year. What is the best plan for her?
- A. Initiate daily fiber supplements with magnesium hydroxide as needed and obtain a gastroenterology consult for a repeat colonoscopy
- B. Check her thyroid function and initiate daily fiber supplements and magnesium hydroxide as needed
- C. Initiate fiber supplements and magnesium hydroxide as needed and offer her psychological counseling for her symptoms
- D. Discontinue the diltiazem and place her on an ACE inhibitor
Show answer and rationale
Correct answer: D — Discontinue the diltiazem and place her on an ACE inhibitor
New onset of constipation will most often have a nonfunctional cause. In this case, the most likely cause is the change of antihypertensives to a calcium channel-blocker. These medications are more often associated with constipation than are $\alpha$-blockers. New-onset constipation can sometimes be a symptom of colon cancer (Answer A), but this would be less likely in a patient that had a recent negative colonoscopy. One could consider a repeat colonoscopy should the constipation be persistent after addressing more likely causes. Constipation may also be secondary to hypothyroidism (Answer B), and one should be suspicious of hypothyroidism (especially in females and elderly patients). However, the calcium channel-blocker is a more likely cause than is noncompliance with a reasonable dose of thyroid medication in this social worker that cares for her disabled husband. Similarly, stress may play a role in her constipation, but the correlation between medications and the constipation should be addressed first and is more likely to be helpful.